Transcriptional activation: risky business.
نویسنده
چکیده
Transcriptional regulation is all about getting RNA polymerase to the right place on the gene at the right time and making sure that it is competent to conduct transcription. Traditional views of this process place most of their emphasis on the events that precede initiation of transcription. We imagine a promoter-bound transcriptional activator (or collection of activators) recruiting components of the basal transcriptional machinery to the DNA, eventually leading to the recruitment of RNA polymerase II and the onset of gene transcription. Although these events play a crucial role in regulating gene expression, they are only half the story. Correct regulation of transcription requires that polymerase not only initiates when and where it should, but that it stops initiating when no longer appropriate. But how are the signals from transcriptional activators, telling RNA polymerase to fire, terminated? Is this process governed by chance, with activators simply falling off the promoter at a certain frequency? Or is there some more direct mechanism, whereby activators are aggressively limited from uncontrolled promoter activation? A new article by suggests the latter may be true, and provides a mechanism for how a component of the basal transcription machinery can mark the activators it has encountered, sentencing them to an early death or banishing them from the nucleus. The ability of the basal transcriptional apparatus to mark activators provides an efficient way to limit activator function and ensures that continuing transcription initiation at a promoter is coupled to the continuing synthesis and activation of transcriptional activators.
منابع مشابه
Does the Ability to Make a New Business Need More Risky Choices during Decisions? Evidences for the Neurocognitive Basis of Entrepreneurship
متن کامل
Corporate Credit Spreads and Business Cycles∗
I study the implications of fluctuations in corporate credit spreads for TFP and output. Motivated by that corporate credit spreads are countercyclical, I build a simple model in which the difference in default probabilities on corporate debts leads to the spread in interest rates paid by firms. In the model, firms finance their capital by issuing one-period bonds, and differ in the variance of...
متن کاملThe relationship between behavior brain systems and impulsivity with high-risk sexual behavior
The purpose of this study was to investigate the relationship between brain systems behavior and impulsivity, with high-risk sexual behavior. The review was detailed co-relational research. The population consists of all undergraduates of universities in Mashhad were enrolled in the academic year 1396. A total of 100 students male volunteered and were chosen using the sampling method. Data was ...
متن کاملAn fMRI Study of Risky Decision Making: The Role of Mental Preparation and Conflict
Introduction: The current study aimed to elucidate the role of preparatory cognitive control in decision making and its neural correlates using functional Magnetic Resonance Imaging (fMRI). To this effect, by employing a series of new cognitive tasks, we assessed the role of preparatory cognitive control in monetary (risky) decision making. Methods: The participants had to decide between a...
متن کاملTranscriptional Coactivator CBP Facilitates Transcription Initiation and Reinitiation of HTLV-I and Cyclin D2 Promoter
HTLV-I is the etiologic agent for adult T-cell leukemia/lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Taxi, the major activator of this virus, is a 40- kDa (353 amino acid) phosphoprotein, predominantly localized in the nucleus of the host cell, which functions to trans-activate both viral and cellular promoters. Recently it has been shown that HTLV-I a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Genes & development
دوره 15 9 شماره
صفحات -
تاریخ انتشار 2001